2021 Louisville Cardinals Football Schedule

Date   Opponent Time/TV Tickets
Monday
Sep 6, 2021
Ole Miss Rebels Logo Ole Miss Rebels
Mercedes-Benz Stadium, Atlanta, GA
8:00 PM ET
ESPN
Lost 43-24
Saturday
Sep 11, 2021
Eastern Kentucky Logo Eastern Kentucky Colonels
Cardinal Stadium, Louisville, KY
7:00 PM ET
ACCNX
Won 30-3
Friday
Sep 17, 2021
Ucf Logo UCF Knights
Cardinal Stadium, Louisville, KY
7:30 PM ET
ESPN
Won 42-35
Saturday
Sep 25, 2021
Florida State Seminoles Logo at Florida State Seminoles
Doak Campbell Stadium, Tallahassee, FL
3:30 PM ET
ESPN2
Won 31-23
Saturday
Oct 2, 2021
Wake Forest Demon Deacons Logo at Wake Forest Demon Deacons
Truist Field, Winston-Salem, NC
12:30 PM ET
RSN
ESPN3
Lost 37-34
Saturday
Oct 9, 2021
Virginia Cavaliers Logo Virginia Cavaliers
Cardinal Stadium, Louisville, KY
3:00 PM ET
ACCN
Lost 34-33
Saturday
Oct 16, 2021
Bye Week
Saturday
Oct 23, 2021
Boston College Eagles Logo Boston College Eagles
Cardinal Stadium, Louisville, KY
4:00 PM ET
ACCN
Won 28-14
Saturday
Oct 30, 2021
Nc State Wolfpack Logo at NC State Wolfpack
Carter Finley Stadium, Raleigh, NC
7:30 PM ET
ACCN
Lost 28-13
Saturday
Nov 6, 2021
Clemson Tigers Logo Clemson Tigers
Cardinal Stadium, Louisville, KY
7:30 PM ET
ACCN
Lost 30-24
Saturday
Nov 13, 2021
Syracuse Logo Syracuse Orange
Cardinal Stadium, Louisville, KY
12:00 PM ET
RSN
ESPN3
Won 41-3
Thursday
Nov 18, 2021
Duke Blue Devils Logo at Duke Blue Devils
Wallace Wade Stadium, Durham, NC
7:30 PM ET
ESPN
Won 62-22
Saturday
Nov 27, 2021
Kentucky Wildcats Logo Kentucky Wildcats
Cardinal Stadium, Louisville, KY
7:30 PM ET
ESPN2
Lost 52-21
Tuesday
Dec 28, 2021
Air Force Logo Air Force Falcons
First Responder Bowl

Gerald J. Ford Stadium, Dallas, TX
3:15 PM ET
ESPN
Lost 31-28